Related Papers
Plasma Cystatin C is Elevated in the Absence of Acute Kidney Injury Following Cisplatin with Contemporary Antiemetics
Melvin T M Chin
Pediatric Nephrology
Jga of Developing, Healthy and Nephrotic Human Kidneys Co -Express Renin and Connexins
2019 •
Merica Glavina-durdov
Pediatric Nephrology
Abstracts of the 18th Congress of the International Pediatric Nephrology Association, Venice (Italy), October 2019
2019 •
Katarina Vukojevic
Acta histochemica
Expression of renal vitamin D receptors and metabolizing enzymes in IgA nephropathy
2021 •
Marijan Saraga
AIM One of the main causes of end-stage renal disease (ESRD) in the world is IgA nephropathy (IgAN). Since kidney is a key player in vitamin D metabolism, we investigated the expression of renal vitamin D receptors (VDR) and metabolizing enzymes in IgA nephropathy patients (IgAN-P). METHODS The sample included twelve IgAN-P who underwent ultrasound-guided renal biopsies and five controls who underwent nephrectomy due to clear renal carcinoma. Immunofluorescent staining was used to determine the expression of VDR, 25-hydroxyvitamin D3 -alpha-hydroxylase (1alpha-OHase) and vitamin D3 24-hydroxylase (CYP24A1). RESULTS Significant increase in expression of VDR, which was prominent in distal tubular cells (DTCs) in tissues from IgAN-P, was found in comparison to the controls (p = 0.0368). The expression of 1alpha-OHase, calcitriol synthesizing enzyme, was significantly lower in IgAN-P, in comparison with controls (p < 0.0001). The opposite, expression of CYP24A1 (vitamin D degrading e...
Chronic kidney disease (CKD) is not renal replacement therapy (RRT): the CKD. QLD registry dataset
Andrew Mallett
NDT Plus
Sunday, June 27, 2010: Poster Session 2
2010 •
cleo fregonese
The Impact of Serum Creatinine Adjustment for Fluid Balance on Diagnosis of Acute Kidney Injury in Critically Ill Patients
Kianoush Kashani
Background: Fluid accumulation may delay recognition of acute kidney injury (AKI) in ICU patients commonly developing volume overload. This study aims to evaluate the impact of fl uid balance on the diagnosis of AKI and associated outcomes in critically ill patients. Methods: This is a single-center retrospective observational study conducted at a tertiary referral hospital. All adult ICU patients between January and March 2010 with at least one serum creatinine (SCr) measured in ICU were included. Patients with end stage renal disease or on dialysis before the ICU admission were excluded. AKI was defi ned as an absolute increase in SCr in ICU of ≥ 0.3 mg/dl or relative change of ≥ 50% from baseline. AKI was identifi ed before and after serum creatinine adjustment for fl uid balance. We used the following formula for the correction factor [admission body weight (kg) * 0.6 + cumulative fl uid balance (L) ]/ [admission body weight * 0.6]. Results: A total of 563 patients were enrolled...
Biology of Reproduction
Transcriptional and Translational Heterogeneity among Neonatal Mouse Spermatogonia
Daijin Ko
Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia responsible for ongoing spermatogenesis in mammalian testes. SSCs arise from morphologically hom*ogeneous prospermatogonia, but growing evidence suggests that only a subset of prospermatogonia develops into the foundational SSC pool. This predicts that subtypes of undifferentiated spermatogonia with discrete mRNA and protein signatures should be distinguishable in neonatal testes. We used single-cell qRT-PCR to examine mRNA levels of 172 genes in individual spermatogonia from 6-day postnatal (P6) mouse testes. Cells enriched from P6 testes using the StaPut or THY1+ magnetic cell sorting methods exhibited considerable heterogeneity in the abundance of specific germ cell and stem cell mRNAs, segregating into one somatic and three distinct spermatogonial clusters. However, P6 Id4-eGFP+ transgenic spermatogonia, which are known to be enriched for SSCs, were more hom*ogeneous in their mRNA levels, exhibiting un...
IgA Nephropathy and Kidney Transplantation: Recurrence Rate in the Graft and Long Term Outcomes
G. Zavos
Background: To estimate the recurrence rate of IgA Nephropathy (IgAN) in the graft, and also compare the long term outcomes of these patients with those of kidney transplant recipients with other primary diseases. Methods: We studied all patients who were transplanted in our hospital between 2000 and 2013, had biopsy proven IgAN in the native kidneys, and follow up time longer than 1 year post KTx. Every patient with IgAN was matched with 2 controls, using the following criteria: primary disease, age, gender, time of KTx, and donor source. Patients with Henoch-Schonlein purpura or with a history of non-compliance were excluded. The groups were compared with respect to patient and graft survival, and renal function at the end of follow up. We also recorded the rate of IgAN in the graft and its impact in graft survival. Results: Between 2000 and 2013, 70 patients with biopsy proven IgAN were transplanted in our center. 67 patients with IgAN and 144 matched controls were included in th...
Direct Healthcare Costs Related to End Stage Renal Disease in Patients New to Haemodialysis: The FARO2 Study
Umberto Di Luzio Paparatti
