Erythrocyte membrane-camouflaged mesoporous silica composite nanoparticles for loading and controlled release of the hepatoprotective agent silibinin: A-synthesis and physicochemical characterization (2024)

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Volume 76 Issue 8 August 2024
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Vahid Tayebi Khorrami

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

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,

Mohammad Javad Raee

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

Student Research Committee, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

Correspondence: Shiraz University of Medical Sciences, Shiraz 7146864685, Iran. E-mail: raeem@sums.ac.ir (M.J.R.); abolmaali@sums.ac.ir (S.S.A.)

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Samira Sadat Abolmaali

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

Correspondence: Shiraz University of Medical Sciences, Shiraz 7146864685, Iran. E-mail: raeem@sums.ac.ir (M.J.R.); abolmaali@sums.ac.ir (S.S.A.)

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Mina Shafiee

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences

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Shiraz 7146864685

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Iran

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Ali Mohammad Tamaddon

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences

,

Shiraz 7146864685

,

Iran

Pharmaceutics Department, School of Pharmacy, Shiraz University of Medical Sciences

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Shiraz 7146864685

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Iran

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Journal of Pharmacy and Pharmacology, Volume 76, Issue 8, August 2024, Pages 995–1005, https://doi.org/10.1093/jpp/rgae046

Published:

19 May 2024

Article history

Received:

13 October 2023

Accepted:

17 April 2024

Published:

19 May 2024

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    Vahid Tayebi Khorrami, Mohammad Javad Raee, Samira Sadat Abolmaali, Mozhgan Abedanzadeh, Mina Shafiee, Ali Mohammad Tamaddon, Erythrocyte membrane-camouflaged mesoporous silica composite nanoparticles for loading and controlled release of the hepatoprotective agent silibinin: A-synthesis and physicochemical characterization, Journal of Pharmacy and Pharmacology, Volume 76, Issue 8, August 2024, Pages 995–1005, https://doi.org/10.1093/jpp/rgae046

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Abstract

Objectives

Milk thistle has long been used in the treatment of liver and biliary disorders. In the present study, to make a long-acting delivery system for silibinin (SBN, a major active constituent of milk thistle seeds with antioxidant and hepatoprotective function), mesoporous silica composite nanoparticles (NC) were synthesized and coated with RBC membrane.

Methods

A modified Stöber method was used for NC synthesis, which was then characterized using FE-SEM, DLS, TEM, FTIR, and EDAX techniques. A suitable lysis buffer was used to prepare RBC-ghost, and sonication was used to coat SBN-loaded NC (SBN-NC). The RBC-ghost coated SBN-NC (SBN-NC-RBCG) was evaluated by SDS-PAGE, Bradford, TEM, EDAX, and DLS methods. SBN release was then compared for the SBN-NC and SBN-NC-RBCG samples.

Key findings

the RBC membrane proteins were recovered from the coating of SBN-NC-RBCG, and SBN release was sustained over 24 h when compared with the SBN-NC.

Conclusions

Overall, through prolonging circulation in the bloodstream and evading the immune system, the developed system can improve SBN bioavailability in liver inflammation and fibrosis conditions that need further research.

drug delivery, liver fibrosis, mesoporous silica, red blood cell, cell membrane, silibinin

© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

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Erythrocyte membrane-camouflaged mesoporous silica composite nanoparticles for loading and controlled release of the hepatoprotective agent silibinin: A-synthesis and physicochemical characterization (2024)
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